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Project description:

Cerebral organoids, 3D models of human neocortical development were first described in 2013 [1], but to date still have only limited capacity to recapitulate human neocortical development. A promising approach is Organ-on-chip (OoC) technology, which could integrate various types of cells in tissue-specific micrometer scale environments to mimic physiological organ-level functions[2]. We aim to apply microfluidic technology to establish a new generation of human brain organoid models to understand neurodevelopment.

[1] Lancaster, M.A., et al. Nature, 2013. 501(7467): p. 373-9.

[2] Achberger, K., et al. Elife, 2019. 8.

Project goal:

To fabricate the brain organoid chip and to understand the human neurodevelopmental processes. After successful implementation of the chip platform, cortical differentiation on chip study will be performed.

What you will learn:

  • Basic microfabrication methods and microfluidic technology
  • Basic and advanced cell culture methods (suspension, 2D and 3D)
  • Optical and biochemical analysis methods of cells/microtissues

Desirable skills of the candidate:

  • Basic cell culture and microscopy
  • Lab benchwork experience
  • Basic understanding of brain development

To apply, please send an email with your application documents (pdf only) to peter.loskill@uni-tuebingen.de.

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