#Talking3RScience Webinar Serie

Roser Vento-Tormo

Wellcome Sanger Institute

“Mapping the Development and Regeneration of Reproductive Tissues“

The study of reproductive tissues requires a systems biology approach. Their development starts in utero and does not finish until after puberty, leading to changes in organization and cell composition across the lifespan via paracrine (e.g. folliculogenesis) and endocrine (e.g. menstrual cycle) signals. Roser Vento-Tormo’s team has generated a comprehensive map of human developing and adult reproductive tissues using a combination of single-cell and spatial transcriptomics, chromatin accessibility assays and fluorescent microscopy. They utilise this map to study the aetiology of reproductive disorders, identify novel therapeutic targets, and guide the development of in vitro models.